He did it in disregard of any advice.

他不顾一切劝告做了这件事。

youdao

They adopted the decision in disregard of our repeated warnings.

他们置我们的多次警告于不顾，采纳了该项决定。

youdao

Star singers, painters and calligraphers, authors… all go in for self-packaging overtly in disregard of public ridicule.

包装歌星、包装书画家、包装著作……包装早已是堂而皇之的事业，不怕社会讥讽了。

youdao

More importantly, the Homeric heroes are said to be bad role models for those who follow them, they are shown to be intemperate in sex, into these vices Socrates adds cruelty and disregard for the dead bodies of one's opponents.

最重要的是，荷马英雄们被说成是坏榜样,对他们的追随者而言，他们都太过纵欲、,还有被苏格拉底冠以残忍,与漠视对手尸体的恶行。

耶鲁公开课 - 政治哲学导论课程节选

Complete disregard of life is rampant in some terrible laboratories.

在一些实验室内，这种毫不重视生命的做法十分猖獗。

需要动物实验吗？ - SpeakingMax英语口语达人

Once, when he saw a new building that he thought the community had erected for itself, in disregard of the rule of poverty, he climbed up to the roof and began prying off the tiles and throwing them to the ground.

NEWYORKER: Rich Man, Poor Man

The World Conference on Human Rights expresses grave concern about continuing human rights violations in all parts of the world in disregard of standards as contained in international human rights instruments and international humanitarian law and about the lack of sufficient and effective remedies for the victims.

UNESCO: Vienna Declaration and Programme of Action

Maududi on Shariah Law's precedence over any other legal system (Islamic Law and Its Introduction, p. 13): That if an Islamic society consciously resolves not to accept the Sharia, and decides to enact its own constitution and laws or borrow them from any other source in disregard of the Sharia, such a society breaks its contract with God and forfeits its right to be called 'Islamic.

CENTERFORSECURITYPOLICY: ISNA's Ingrid Mattson in her own words