My relationships with friends have been irrevocably altered by their reactions to my illness.

由于朋友们对我的病情所做出的反应，我和他们的关系已经彻底改变了。

《柯林斯英汉双解大词典》

The events with Treya changed me deeply, profoundly, irrevocably.

和崔雅在一起的经历对我的改变浓烈，深刻，不可磨灭。

youdao

Watching Late Night Gimp Fight made me think I had irrevocably crossed a line.

在看《深夜打架的瘸子》时，让我想到我不可避免地跨过了一条线。

youdao

"We enjoy the fruits of prejudice and bigotry being lifted - slowly, sometimes,in fits and starts, but irrevocably - from human hearts.

VOA: standard.2010.01.17

When the perpetrator of abuse is a priest a sacred trust has been irrevocably betrayed.

BBC: Parish priest involved in Donagh abuse case

What's certain, however, is that the contest over reform in Indonesia has been irrevocably radicalized.

CNN: ASIANOW - TIME Asia

The big break in the momentum means the stock game has changed irrevocably for Netflix.

FORBES: Netflix Crushes Its Own Momentum