It is an big problem how to fulfil different QoS requirement of various application by suitable allocating resource of network.

如何通过网络资源的合理分配来满足不同应用之间的服务质量要求，是一个很重要的问题。

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What happened in La Gloria was an unfortunate coincidence with a big and serious problem that is happening now with this new flu virus.

奥乔亚说，“在拉格罗利亚发生的事情，很不巧与现在新病毒带来的广泛而严重的问题撞在了一起。”

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"I think we can say there is a big public health problem here," says Professor Andrew Watterson, an occupational health specialist at Stirling University.

“我想我们可以说这是一个比较大的公共健康问题，”安德鲁·沃特森教授说，他是斯特林大学的专业健康专家。

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It's also an escape. A big problem we have in the neighborhood is obviously gangs,and family dynamics.

VOA: special.2010.11.04

Hoarded cash is a big problem for an economic recovery.

FORBES: Lots Of Cash Not Being Spent Will Choke Off The Recovery

The problem is an enduring fetish to store big data without making plans for how it will be used.

FORBES: Curing the Big Data Storage Fetish

"The patterning issue is a very big problem, " Choi Sang-hun, an LG Display engineer, said in an interview.

WSJ: TV Makers Seek Fatter Profits in Thinner Sets