There is nothing we can do about it. It's a lost cause.

我们已经无能为力了，它是注定要失败的。

youdao

For many years he supported the development of the electric car, but he now thinks it's a lost cause.

多年来他一直支持电动汽车的研制，但是现在却认为这个项目肯定没希望。

youdao

He wants very much to get a job in the film industry, and he takes no notice of me when I tell him it's a lost cause.

他很想在电影行业中找一份工作，我告诉他这是失败的事业，他却没把它放在心上。

youdao

However, the commentator says that this time, his party, the Il Popolo della Liberta (PdL) or The People of Freedom, will be less likely to spring to his defence, as it is now beginning to see Mr Berlusconi's war against the judiciary as a lost cause.

BBC: Italian press writes Berlusconi's political obituary