Many people graduate from school or college not knowing what to do with their lives, and get a job without really thinking about it.

很多人从学校或大学毕业，却不知道该做什么工作谋生，然后没有真正思考就找了个工作。

youdao

I stood there blankly, not knowing what to do.

我茫然地站在那里，不知道该怎么办。

youdao

Knowing what to do is not the same as being able to do it.

知道做什么和能够做什么是不一样的。

youdao

I think that what you have to do as a young person is develop your human capital and that means knowing how to do things.

我认为作为一个年轻人 你们应该做的,是发展你们的人力资本,而这意味着你们要知道怎样做事情

耶鲁公开课 - 金融市场课程节选

One should do," he says, "what archers do when attempting to reach a distant target, namely, aim your bow high, knowing that the force of gravity " will bring the arrow down."

他说：，“一个人应该做的是，模仿伟人所为,当试图达致遥不可及的目标时，意即将目标设高，明了重力会将,射出的箭吸回地面“

耶鲁公开课 - 政治哲学导论课程节选

So it's worth knowing in a general way what you need to do to earn a good grade in discussion section and here the answer is, perhaps the obvious one, you need to participate.

现在值得让你们知道什么是你们要做的,去得到好的分数在课堂讨论并且答案是，也许最显然的一个是，你需要去参与。

耶鲁公开课 - 死亡课程节选

Knowing what to do, however, doesn't mean it's going to be easy to do it.

FORBES: Magazine Article

Finally, one of them made a remark about people not knowing what to do with their lives.

NEWYORKER: Silence, Exile, Punning

Adults can be discouraged from exercising by not knowing what to do or how to do it.

WSJ: Hard-Wired to Hate Exercise?