• 白茅根 - 引用次数：1

  On the basis of the function and treatment as well as the characters of the component of the herbs,the optimum extract conditions were selected by using orthogonal design. Forsythia suspense,using 8 times water to soak for 2 hours,then dest 6 hours to extract essential oil and usingβ-CD to clathrate it,collect the water-solution after extraction;agrimoniae,lalang grass rhizome, forsythia suspensa's gruffs after extracting and other four herbs,using water to decoct for 3 times,8 times water and 2 hours for one,collect the water-solution,flit and concentrate to extractum whose relative density is 1.15～1.21(60～70℃);the rest agrimoniae and lalang grass rhizome was crashed to fine powder;granulating according to marumerization with those fine powder as carrying agent and extractum as adhesive material,the condition as below:rate of gaining:50～60ml/min;pressure of atomization:0.12Mpa;frequency of atomization:4.0Hz;material temperature:60～80℃;warming temperature:105℃;out temperature:80℃,then rimming the granula,addingβ-cyclodextrin inclusion compound and amidon 10g,tabletting to 1000, then coating with Opadry.

  根据处方的功能主治及药物所含成分的理化性质,采用正交实验方法以多指标综合评分筛选最佳工艺为:以上七味,取连翘,加8倍量水,浸泡2小时,蒸馏6小时,提取挥发油,备用;药液滤过,滤液另器保存,备用;取16gβ-环糊精,溶于120ml水,加入上述挥发油,在40℃的条件下超声包合20分钟,滤过,40℃干燥4小时,研磨,过100目筛;药渣与部分仙鹤草、白茅根及其余四季红等四味加水煎煮三次,每次加8倍量水,每次2小时,合并煎液,滤过,滤液浓缩至相对密度为1.15～1.21(60～70℃)的清膏;取剩下部分仙鹤草、白茅根粉碎成细粉,过100目筛,混匀;取上述细粉作为载体,以清膏作为粘合剂,按以下条件进行一步制粒:进液速度:50～60ml/min;喷雾压力:0.12Mpa;喷雾频率:4.0Hz;物料温度:60～80℃;加热温度:105℃;出风温度:80℃,得干燥颗粒,整粒,加入β-环糊精包合物及10g淀粉,混匀,压成1000片,包薄膜衣,即得。

  参考来源 - 康泌安片的药学部分研究

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