Conclusion: Obesity in humans may be due to leptin resistance rather than to leptin deficiency.
结论：人类肥胖的发生可能与瘦素抵抗而不是瘦素缺乏有关。
Leptin maybe regulate the generation of obesity through acting on the proliferation and differentiation of preadipocyte at the state of leptin resistance and high leptin concentration in serum.
瘦素抵抗、血清高瘦素浓度等病理状态时，瘦素可能影响前脂肪细胞的增殖及进一步分化为脂肪细胞，调节肥胖发生。
Many obese people have developed a resistance to the appetite-suppressing effects of leptin and never feel satisfied, no matter how much they eat.
很多肥胖的人已经形成了一种对消瘦素抑制食欲效应的抵抗，不管他们吃多少也从不感到满足。
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