Myocardial interstitial fibrosis,a great quantity of collagen deposition and distribution abnormality of collagen fiber in DM patients were important causes of DCM.2. The area and degree of fibrosis in DCM were significantly larger and heavier than that in control group.
2.糖尿病患者心肌间质纤维化面积及程度比对照组明显增加,提示糖尿病患者心肌间质的纤维化可能是导致其心脏并发症重要因素之一。
参考来源 - 糖尿病心肌病的组织病理学及与心肌纤维化相关细胞因子TGF·2,447,543篇论文数据，部分数据来源于NoteExpress
Objective To investigate the mechanism of reversion of myocardial interstitial fibrosis in diabetic cardiomyopathy (DCM) by valsartan.
目的探讨缬沙坦逆转糖尿病心肌病(DCM)心肌间质纤维化的作用机制。
ACEI reduces the levels of ACEmRNA directly and significantly inhibits the progression of myocardial interstitial fibrosis and cardiac remodeling.
臼acei可直接下调ace测a表达，有效地抑制了心肌间质纤维化，阻止心肌重塑的发生。
CONCLUSION: Myocardial interstitial fibrosis and the reduction of myofibril elements are the major pathological basis for the impairment of cardiac function in patients with DCM.
结论：DCM患者心肌间质纤维化，肌原纤维减少是扩张型心肌病心功能损害的主要病理基础。
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