The airport looks exactly like every other major modern airport in Europe, except for one big problem.

这个机场看起来和欧洲其他主要的现代化机场一模一样，除了有一个大问题。

youdao

One big problem is: what will happen if the flying cars break down?

有一个大问题是：如果飞行汽车坏掉了会发生什么？

youdao

But there was one big problem.

但是有一个很大的问题。

youdao

Critics say one big problem is corruption.

VOA: special.2009.02.21

Piaget was really big into question and answer, but one problem with this is that children aren't very good with language, and this might lead you to underestimate how much they know.

皮亚杰非常热衷用问与答的方法进行研究,但这里存在的一个问题便是,儿童并未能完全掌握语言,这可能会导致你低估他们的理解能力

耶鲁公开课 - 心理学导论课程节选

There is one big problem with this explanation, which is clearly designed to help Fox.

BBC: Fox financial backer speaks

Many iPad owners say they love their devices except for one big problem: the gadget is all screen.

WSJ: Greasy Smudges Frustrate iPad Owners

One big problem: Sky Angel distributes its signals over the Internet instead of a conventional cable-TV system.

FORBES: The Tiny TV Broadcaster That Cable And Internet Giants Are Trying To Kill