The role will be one of the biggest challenges of his acting career.

这个角色将是他演艺生涯中最大的挑战之一。

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One of the biggest challenges facing employers and educators today is the rapid advance of globalization.

当今雇主和教育工作者面临的最大挑战之一是全球化的快速发展。

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One of the biggest challenges you'll ever face is motivation.

你遇到的最大的挑战就是动机。

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But President Obama recognized that, for the most part, Republican opposition remains one of the biggest challenges to his plans.

VOA: standard.2009.10.10

One of the biggest challenges to date has been related to cultural relativism.

在那之后的诸多挑战中,最值得一提的就是，“文化相对主义“

普林斯顿公开课 - 人性课程节选

Department of Homeland Security Secretary Janet Napolitano says one of the biggest challenges is finding the right people to handle the job.

VOA: standard.2009.08.11

One of the biggest challenges of retirement planning is to estimate your future expenses.

FORBES: Retirement Is Blocked By The Revolving Door

"Food security is one of the biggest challenges we currently face, " said ABC's chairman Julian Little.

BBC: UK urged to lead on future food

One of the biggest challenges is the requirement to keep from drifting more than 1, 076 square feet.

WSJ: Flight of Fancy: The Sky's the Limit for Team That Rises to the Occasion