A]一线治疗晚期结直肠癌， TREE-2 组为上述化疗方案+BV治疗。试验结果显示， TREE-1 组总体有效率（ overall response rates， ORR）分别为 41%、 20%和27%，中位OS分别为19.2、 17.9和17.2个月； TREE-2组
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Several newer targeted therapies offer advantages to patients that include decreased side effects, higher overall response rates and better tolerance for older patients.
一些更新的靶向治疗使患者受益良多，其中包括减少副作用，提高整体反应率并增强老年患者的耐受性。
The use of response rates is usually confined to Phase II, as it has been shown that the relation to overall survival is not always present.
反应率通常仅限于在二期试验中，因为它已经说明与整体生存率的关系并非始终存在。
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