Objective:To evaluate the feasibility of transcatheter closure of patent foramen ovale(PFO)to prevent paradoxical embolism with Amplatzer occluder device.

目的：经导管封堵卵圆孔未闭（PFO）预防脑的矛盾栓塞并评价其疗效。

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One theory on why cryptogenic strokes occur in younger people in their 40s and 50s is that the flap known as a patent foramen ovale, or PFO can allow blood clots to reach the brain, physicians say.

WSJ: Doctors Debate Whether Strokes Be Prevented With a Heart-Plug Procedure

The PC T rial (Clinical Trial Comparing Percutaneous Closure of Patent Foramen Ovale Using the Amplatzer PFO Occluder with Medical Treatment in Patients with Cryptogenic Embolism) randomized 414 patients with PFO who had had an ischemic stroke, TIA, or a peripheral thromboembolic event to either medical therapy or PFO closure with the Amplatzer PFO Occluder.

FORBES: Controversial PFO Closure Trials Published In NEJM