In midbrain slices from rats treated with saline or a single dose of cocaine, LTP could not be induced in VTA dopamine neurons unless GABA-mediated inhibition was reduced by bicuculline or picrotoxin.
在大鼠的中脑切片中利用盐或单剂量的可卡因进行处理并不能在腹侧被盖区诱发ltp的产生，只有在利用荷包牡丹碱或苦味毒减弱gaba(氨基丁酸)介导的抑制作用时才可以观察到LTP的出现。
Objective to observe the kindling model of Sprague Dawley (SD) rats induced by injection of different doses of picrotoxin (PTX) intraperitoneally, and to evaluate the effect of the drug on the model.
目的：观察不同剂量印防已毒(PTX)致SD鼠慢性点燃癫痫模型及药物对该模型的影响。
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