This study was designed as randomized, double-blind and crossover trials.

本研究是采取随机、双盲、交叉试验设计。

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These patients had acne vulgaris ranging from mild to severe and were a subgroup of patients from phase 3, randomized, double-blind, vehicle-controlled, multicenter clinical trials.

这些患者有轻到重度痤疮，是基质对照随机双盲多中心3期临床试验的一个亚组。

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The methodological quality of included trials was generally "poor." Few trials reported methods of randomization. Three trials were randomized, double blind, and placebo-controlled.

很少有实验报道随机取样的方法。内含的试验方法的质量一般很弱。三种试验分别为随机取样、双盲法、安慰剂给样试验。

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Safety data for KYNAMRO are based on pooled results from four Phase 3, randomized, double-blind, placebo-controlled trials with a total of 390 patients of which 261 patients received weekly subcutaneous injections of 200 mg of KYNAMRO and 129 patients received placebo for a median treatment duration of 25 weeks.

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