Conclusion: H_2 receptor antagonists induce the desensitization of the H2 receptor on the the rat gastric parietal cell, but proton pump inhibitors do not have tolerance.

结论H 2受体拮抗剂能够诱导壁细胞H 2受体出现脱敏，质子泵抑制剂未出现耐受现象。

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CONCLUSION: Three H2 receptor antagonists can induce different desensitization of the H2 receptor, among which famotidine induces the strongest and cimetidine does the weakest.

结论：三种H 2受体拮抗剂对壁细胞H 2受体脱敏的诱导能力存在一定的差别，其中法莫替丁最强，西咪替丁最弱。

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