Obesity has already become the main cause of less serious forms of liver disease, but cirrhosis is the end stage - an irreversible scarring that causes the organ to deteriorate.

肥胖早已成为导致严重程度较轻的肝病的主要原因，但肝硬化是肝病的终极阶段———个导致肝器官恶化的无可治愈的病情。

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"These aggregates of ATZ accumulate in the liver cells and eventually lead to scarring, or fibrosis, of the organ and set the stage for tumor development," Perlmutter said in a statement.

Perlmutter博士在一篇声明中称，“这些AT Z聚集体在肝细胞中堆积，最终导致肝脏瘢痕形成、纤维化，为肿瘤的发生创造条件。”

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By the time a biopsy confirms the diagnosis, the disease is in its chronic stage, often with severe scarring of the liver and the threat of cancer and death.

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