然而,在携带有危险等位基因的纯合子型人群中,仍有1/3的人获得了持续病毒学应答(sustained virological response,SVR),所以单纯考虑宿主因素并不能解释丙型肝炎抗病毒治疗的疗效,病毒对IFN治疗的影响也同样值得注意。
基于30个网页-相关网页
...复发患者的III期研究(RESPOND-2)结果表明:Boceprevir联合SOC显著增加患者持续病毒学应答率(Sustained Virological Response,SVR),Boceprevir+SOC的三联治疗耐受性良好,但与SOC组相比,三联治疗组贫血与味觉障碍的发生...
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...复发患者的III期研究(RESPOND-2)结果表明:Boceprevir联合SOC显著增加患者持续病毒学应答率(Sustained Virological Response,SVR),Boceprevir+SOC的三联治疗耐受性良好,但与SOC组相比,三联治疗组贫血与味觉障碍的发生...
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因此, TPR(telaprevir, peg-IFNα, RBV)联合治疗可有效提高患者的持续病毒应答(sustained virological response, SVR), 并降低抗药突变的发生率.
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sustained virological response svr 即持续病毒学应答
Objective:To discuss the influential factors of sustained virological response(SVR) rates in the treatment of chronic hepatitis C with the combination of peginterferonα-2a and ribavirin. To study the relationship among HCV genotypes,rapid/early response and SVR.
目的:探讨PEG-IFNα-2a联合利巴韦林治疗慢性丙型肝炎的持续应答率的影响因素,基因型、应答状况及持续应答率之间的关系,以及个体化治疗对抗病毒疗效的影响。
参考来源 - 聚乙二醇干扰素α·2,447,543篇论文数据,部分数据来源于NoteExpress
Standard of care resulted in sustained virological response (SVR) rates of 38% and 81% in treatment-experienced and treatment-naïve patients, respectively.
标准治疗导致出现持续病毒学反应(SVR)的复治和初治患者比例分别为38%和81%。
These patients have a high likelihood of SVR (Sustained Virological Response) - probably 70-80% - and in the absence of any contraindications of therapy they are very good candidates.
这类患者出现持续病毒学应答(SVR)的机率很高——大概是70%到80%,且无治疗的禁忌症,是非常好的治疗对象。
This will comprise of direct antiviral drugs such as protease inhibitors along with peg-Interferon and ribavirin. This can provide a sustained virological response in over 70% of patients.
应用三联疗法的患者中,超过70%的患者能够达到持续病毒学应答,同时对难治性基因型患者也能获得很好的疗效。
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