The experimental process on synthesis of roxithromycin was studied by using erythromycin oxime and MEMC as raw material under the catalytic action of anhydrous sodium carbonate.
研究了以无水碳酸钠为催化剂，红霉素肟与甲氧基乙氧基氯甲醚(MEMC)为原料，一步合成罗红霉素的实验过程。
The first part: synthesis and in vitro activity of 3-keto-9-o-substituted oxime derivatives of 6-o-methyl erythromycin a.
第一部分：3 -酮基- 6 - O -甲基红霉素- 9 -取代肟基衍生物的合成与体外抗菌活性。
The E configuration of erythromycin oxime was found to transfer easily to the Z configuration to equilibrium under the condition of alkalescence.
碱性条件下红霉素肟容易由E构型转化为Z构型从而达到平衡。
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