Current therapies are powerful but with unintended targets and side effects that can be equivalent to a sea change.

现在的治疗方法虽然作用很强，但是没有特定的靶向，因而会产生同等程度的副作用，就像海浪一样。

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Although initially appealing, the hypothesis of a simple climatic change related to sea levels is insufficient to explain all the data.

与海平面相关的简单气候变化假说虽然起初很吸引人，却不足以解释所有的数据。

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Whether album number three beckons a sea change into unchartered waters remains to be seen, but for now Vampire Weekend’s status as fine purveyors of guitar-orientated pop is firmly cemented.

第三张专辑他们会否有彻底的转变还不得而知，不过眼下乐队作为吉他流行曲供应 者的地位是得到加强了。

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"I think we're on a very good path to making a sea-change in our missile defense posture within the coming three-to-five years."

VOA: standard.2010.03.26

If realized, Carey's proposal would amount to a sea change in how Fox does business.

NPR: Exec Threatens To Pull Fox Signal If Aereo Goes On

It follows that the stronger the links of the chain are, the faster the pitch, which has led to a sea change in the way pitchers train.

WSJ: Baseball 2013: Here Come the Flamethrowers

That seems to be a sea change position.

WHITEHOUSE: Press Briefing