They can sacrifice themselves for you and go to the shopping center together, but they do not enjoy this activity because it is against their nature.

他们肯为你牺牲自己，和你一起去购物中心，但是他们并不喜欢这一活动，因为这违背了他们的本性。

youdao

If you go against nature and do things at the wrong time of year, you will have to do more work and the results will no be so good.

假如你违反自然规律，做事每年在错的时间，你就得付出更多的工作，结果将不那么好。

youdao

To suddenly have options, to have to approach one's bodily functions with a strategy in mind, seems to go against the grain of nature.

WSJ: In the Driver's Seat

But the most obvious way to achieve growth is to open economic and political competition, and that would go against the very nature of Mr Putin's regime.

ECONOMIST: Russia��s familiar next ruler