Objective To analyze the role and location of ubiquitin-dependent proteolysis pathway (UPP) in PC12 cells transfected by plasmids with spinocerebellar ataxia type 3 (SCA3) gene.

目的分析泛素依赖的蛋白水解通路(UPP)在转染了脊髓小脑性共济失调3型(SCA3)基因的PC 12细胞中的定位及作用。

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Actin cleavage by caspase-3 may accelerate ubiquitin/proteosome dependent muscle proteolysis (6).

通过caspase-3剪切的Actin可能加速泛素/蛋白酶体依赖的肌肉蛋白水解（6）。

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