Objective: to investigate the effects of the expression of exogenous brain derived neurotrophic factors (BDNF) on injured spinal cord following in vivo adenoviral gene transfer to the cord.
目的:研究腺病毒介导的脑源性神经营养因子(BDNF)基因在大鼠损伤脊髓内的表达规律,观察外源性BD NF对损伤脊髓的作用。
But it is difficult for exogenous gene to enter brain because of the presence of the blood-brain barrier (BBB). This is the main obstacle for gene transfer therapy in central nervous system.
但血脑屏障的存在却使外源性基因难以进入脑内,是中枢神经系统转基因治疗的主要障碍。
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