The purpose of gene therapy, immune and metabolic regulation can be achieved byadministration of foreign plasmid DNA via the gastrointestinal tract (GI). The possibleinfluence of the absorption and gene transfer of foreign plasmid DNA on the organism hasdrawn considerable attention.
外源质粒DNA通过胃肠道途径吸收可达到基因治疗、免疫和代谢调控的目的。
参考来源 - 外源质粒DNA经胃肠道吸收对小鼠基因表达谱影响的初探·2,447,543篇论文数据，部分数据来源于NoteExpress
To study the influence of foreign plasmid DNA on spleen metabolism in immune-stimulated mice via the gastrointestinal tract.
研究外源质粒dna经胃肠道途径对免疫激活状态下小鼠脾脏代谢的影响。
CONCLUSION: Foreign plasmid DNA, administered via the gastrointestinal tract, may widely modulate the expression of many genes in the intestine in mice.
结论：外源质粒dna通过胃肠道途径可广泛调控肠道多种基因表达。
Foreign plasmid DNA was cleared from cellular system in short time after intramuscular injection. Foreign plasmid can not integrate into host chromosome genomic in the immunized mice.
肌注外源质粒后，外源质粒在小鼠细胞内逐渐被清除，外源质粒不会整合到宿主染色体上。
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