1 新的分化诱导剂 1.1 组蛋白去乙酰基酶抑制剂（inhibitors of histone deacetylase，iHDACs） 近年研究发现，染色体组蛋白乙酰化状态与基因转录密切相关，染色质高乙酰化区含较多的活化转录单位而低...
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The present invention relates to hydroxamic acid derivatives that are inhibitors of histone deacetylase (HDAC).
本发明涉及作为组蛋白脱乙酰基酶（HDAC）抑制剂的异羟肟酸衍 生物。
Histone deacetylase inhibitors increase the acetylation level of histone as well as some non-histone proteins, and specifically modulate some gene expression.
组蛋白去乙酰酶抑制剂可提高组蛋白的乙酰化水平，并对一些非组蛋白成分产生影响，从而调节某些特定基因的表达。
HDAC and histone deacetylase inhibitors (HDI) can affect expression of some specific genes and induce cell differentiation growth arrest and apoptosis through regulating histone acetylation level.
组蛋白脱乙酰基酶与组蛋白脱乙酰基酶抑制剂通过对组蛋白乙酰化水平的调控，影响特定基因的表达，改变细胞周期的进程。
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