Get clearance before making major design changes.

在进行主要的设计变更之前进行清理。

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Their first major design took off in high schools and colleges.

他们的头一个重要的设计在大中学校流行开来。

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Therefore, total events per second is the major design criteria.

因此，每秒钟的事件总量是一个主要的设计标准。

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Street newspaper The Big Issue has undergone a major design and editorial revamp.

BBC: Revamped Big Issue hits streets

About 10 percent of significant findings have resulted in "retrofits or major design changes to the nuclear weapons stockpile, " the IG reported.

CENTERFORSECURITYPOLICY: Center For Security Policy

Functionally obsolete is a different story, Stidger said, explaining that bridges carrying this tag also carry major design problems, diminishing their load-carrying capacity.

CNN: Experts: Leadership, money keys to building bridges