Unfortunately, it showed serious adverse toxicity in the Phase I clinical trial which had to be suspended.
遗憾的是，临床一期实验表明其具有大的毒副作用，不得不中止了进一步的实验。
In this paper, the author want to probe the method how to find one or more acceptable drug dose combinations of two agents used together in a Phase I clinical trial.
本文研究的是在第一阶段临床试验中，寻找两种制剂混合而成药物的最大耐受剂量的方法。
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