甲状腺激素不敏感综合征的临床及其治疗原则 敏感综合征(thyroid hormone insensitivity syndrome,THIS)亦称甲状腺激素抵抗综合征(resistance to thyroid hormone,RTH),首先由Refetoff等于1967年报道.临床表现多种多样,变异性大,可有甲状腺功能正常、亢进或减
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Thyroid hormones decrease systemic vascular resistance by increasing production of nitric oxide and by increasing calcium reuptake within the arterioles, which leads to smooth muscle relaxation55.
甲状腺激素通过增加一氧化氮的产生和通过增加小动脉内的钙再摄取而降低全身血管阻力，这导致平滑肌松弛。
The initial decrease in systemic vascular resistance induced by thyroid hormones leads to decreased perfusion in the kidneys, which increases renin and aldosterone levels59.
甲状腺激素诱导的全身血管阻力的初始下降导致肾脏灌注减少，这增加肾素和醛固酮水平。
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