It was a shattering blow to her pride.

那事彻底摧毁了她的自尊心。

《牛津词典》

The news of his death came as a shattering blow.

他的死讯让人惊愕不已。

《牛津词典》

Self-knowledge or self-realization is to realize for yourself and by yourself that there is no self to realize. That is going to be a shattering blow.

自我开悟或悟道就是自己认识到原本没有一个我去悟，这将是一个毁灭性的打击。

youdao

No, this is not South Africa, where the election of Jacob Zuma as president of the ruling African National Congress on December 18th dealt a shattering blow to his rival, Thabo Mbeki.

ECONOMIST: Democracy in Africa

But perhaps what is most important about all of this is that it is another shattering blow to the reputation of the banking industry, at a time when that reputation - many would say - is already at rock bottom.

BBC: Barclays 'attempted to manipulate interest rates'