Every pill made my insides turn upside down.

每片药都使我的胃翻江倒海。

《柯林斯英汉双解大词典》

In ancient China, there is also a saying, water can hold the boat, it can also make the boat turn upside down.

在中国古代也有谚语说，水能载舟，亦能覆舟。

youdao

Another idea is that the earth will turn upside down. So the North Pole will become the South Pole.

另外一个观点认为，地球会上下颠倒，北极会变成南极。

youdao

It occurred to me here I could take that theme and turn it upside down against itself and it would work.

我突然发现,我能把这个主旋律颠倒过来并合在一起,还挺行得通的

耶鲁公开课 - 聆听音乐课程节选

Why does a particular maiden turn our wits upside down?

为什么一个特别的少女会让我们神魂颠倒？

耶鲁公开课 - 心理学导论课程节选

Rather, such fiscal uncertainty mirrors the very mechanisms we least understand, namely, the destructive powers of nature herself, whose all too earthly ferocity can turn upside down in an instant every philosophy, economic engine and ethic.

FORBES: Japan's Tragedy: Global Ecological Uncertainty

At the gym club, he would pick boys up and turn them upside down, holding them by the legs.

NEWYORKER: In Plain View

Because the market wanted Mark Zuckerberg to turn Facebook upside down, to sell out users and bombard pages with meaningless advertisements.

FORBES: Why Facebook is Still The Internet