The world rarely sees someone who has had such a profound impact on so many.
Retrofit program, and it can have a profound impact on reducing healthcare costs for corporate America.
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But her involvement in the campaign has a profound impact on her family, friends and community.
The actions of the federal government can have a profound impact on financial markets.
This demographic trend will have a profound impact on medical costs, businesses, worker efficiency and productivity.
The greed and hubris displayed on these pages had a profound impact on our economic history.
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None of this is to deny that the unions could again have a profound impact on politics.
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Research suggests that the way we wish to perceive ourselves has a profound impact on how we behave.
This is having a profound impact on the market for developing new tests.
And finally, our newest program which is having a profound impact on education in Chicago is the Saturday University.
These new technologies, combined with demographic shifts and globalisation, will have a profound impact on the future of SMEs.
But one way or another, the case of one errant congressman may have a profound impact on the voting pattern.
The study found that the food in the far corner of the room had a profound impact on these predictions.
Some noted French trends of the past such as Japonisme and Chinoiserie have made a profound impact on French culture.
When integrated into games, virtual worlds and other simulated environments, this technology will have a profound impact on the user's experience.
It's these kind of skills - and others - that would have such a profound impact on teenagers' outlook on life.
Mark Zuckerberg is the youngest billionaire on the planet and created something that has already had a profound impact on the world.
And all of us have to be concerned about a changing climate that could have a profound impact on every single country here.
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All this could have a profound impact on the United States, which in recent years has absorbed about half of each new Mexican generation.
The Lao government has plans to build a series of dams along the Nam Ou River, which would have a profound impact on the area.
Whatever controversy dogged the company with Mass Effect 3 and Dragon Age 2, Bioware has had a profound impact on the ascendance of Western RPGs.
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"If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality, " Westin said.
And so the chances are that if this continues, and there's no reason why it shouldn't continue, it will have a profound impact on the November election.
In Central California, the nation's agricultural powerhouse and a region with one of the highest poverty levels, the 1986 law had a profound impact on people like Mejia.
Revenue sharing also had a profound impact on operating income.
We believe the issues that will be considered by the full court on rehearing will have a profound impact on innovation in the United States for years to come.
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They are known for their innovative work, for creating technologies and platforms that have had a profound impact on the world, particularly in the way in which we function socially.
Even though none of the National Goals for Education has been met, the very process of achieving consensus around a set of objectives turned out have a profound impact on United States education.
Not only did I watch these exceptional young men and women grow up right before my eyes, but they slowly transformed into confident professionals who will have a profound impact on the business of baseball.
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