"What a profound responsibility it is to do this work, " said Dr. Francis Collins, director of the Human Genome Project at the National Institutes of Health.

CNN: Leaders say discovery must be linked to responsible use

Who are the people that really look forward to going to work everyday, who get a profound sense of satisfaction from what they do, who are in jobs they choose and at an income level that is good enough?

FORBES: Who Are The Happiest Workers in America (And Who Is Getting Happier)?

If you are looking for a Zuckerberg legacy it will be found there, long before he learns how to use foreign ATMs. Facebook has provoked us into thinking about a social work place and its impact is profound.

FORBES: Yes But Facebook Did Change Everything About How You Work

The experience was to have a profound effect on his life, and later on his work as an artist.

BBC: Obituary: George Wyllie

But Turin's work challenged the status quo in such a profound way that smell specialists had a tough time believing he was correct.

FORBES: Global Life

They are known for their innovative work, for creating technologies and platforms that have had a profound impact on the world, particularly in the way in which we function socially.

FORBES: The Creative Renaissance

For example, work in the field of epigenetics demonstrates that environment can have a profound influence on how DNA impacts biology.

FORBES: Do Liars Really Have Different Brains?

Very much a work of art rather than of history, this beautifully written novel edges towards saying something profound about the relationships between art and life, men and women, the powerful and the disempowered, without ever becoming a simplistic parable.

ECONOMIST: New fiction (1)