Actos, at least, seems to have some real benefit for diabetics in preventing heart disease.
But there is some evidence that Actos might hit alpha as well as gamma.
The study published on the BMJ website said patients taking Actos had fewer heart problems.
Glaxo conducted another study that did compare Actos and Avandia in another database and found no difference.
Actos, from Japanese pharmaceutical giant Takeda, is the only other drug in the same class as Avandia.
But patients on Actos were significantly more likely to have side effects, including fluid buildup and weight gain.
Rival Actos, from Japanese drug maker Takeda, does not seem to cause heart attacks and may prevent them.
Con motivo del AIQ hay programados toda una serie de actos y eventos apasionantes en todo el mundo.
Actos provides additional insight into how parties and judges are approaching the use of predictive coding technology during discovery.
Since early 2012, however, four new cases have surfaced, including In Re Actos.
Researchers had aimed to prove that Actos also reduced other complications like paralysis, but the trial failed to prove that.
But now, they say, the number of people taking Actos has increased, and they plan to complete a Glaxo-funded study.
Estos actos congregaron a representantes de cada uno de los 50 equipos finalistas, procedentes de todas las regiones del mundo.
Actos and potential successors such as Pargluva work on combinations of these genes, known as peroxisome proliferators activator receptors, or PPARs.
Diabetes occurred at a rate of 7.6% a year in the placebo group and 2.1% a year in the Actos group.
There were a few more heart problems, and three deaths in the Actos group compared to one in the placebo group.
Takeda 's Actos and GlaxoSmithKline 's (nyse: GSK - news - people ) Avandia have a big effect.
All told, these trials involved 3, 725 patients who had received Pargluva, placebo, or Actos, another diabetes drug made by Takeda Pharmaceutical.
But Januvia isn't just a newer version of existing diabetes blockbusters like Avandia, from GlaxoSmithKline, and Actos, from Japan's Takeda Pharmaceutical .
Actos increases "good" cholesterol by about 20% and cuts triglycerides by 10%.
Avandia and Actos are the only two drugs in their class on the market, and they split the market 60% to 40%.
El ser humano debe aprender a tener compromiso con el resultado de sus actos y dejar de creer en el libre alvendrio.
But in clinical trials, fewer deaths seem to happen with Avandia than Actos although that comparison looks more fraught to me.
Although Actos significantly reduced the risk of heart attacks, strokes and death by 16%, that was not the primary aim of ProACTIVE study.
The restriction only to new patients who have already tried Actos is smart, and lines up with what the FDA advisory committee suggested.
The plaintiffs allege a prescription drug for the treatment of type 2 diabetes called Actos increases the risk of bladder cancer in patients.
The study could open new avenues for treating heart disease, aside from being a marketing coup for Japan's Takeda Pharmaceutical, which makes Actos.
In the past several months, studies of Actos and Avandia, from Takeda Pharmaceutical and GlaxoSmithKline, have failed to alleviate safety concerns with those drugs.
According to the analysis, 60 patients would have to be treated with Avandia instead of Actos for one year for one to be harmed.
Takeda sells Actos, the world's top-selling diabetes pill, and Rozerem, a potential threat to sleep drugs like Lunesta and Ambien that so far hasn't taken off.
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