However, in the end, the 2010 British Open champion was no match for Watson.
In July the club will open an 18-hole golf course, designed by former British Open champion Tom Weiskopf.
Former British Open champion Louis Oosthuizen of South Africa, the No. 4 seed, will play Richie Ramsay of Scotland.
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British Open champion Ernie Els tied for 48th after his second successive 73.
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The 19-year-old Italian eagled the third extra hole to deny 2010 British Open champion Oosthuizen his third title of 2012.
Phil Mickelson went into the clubhouse on six-under 136, two ahead of British Open champion Ernie Els of South Africa.
"I do feel a little responsible but I kept fighting to the end, " said Stupples, last year's Women's British Open Champion.
Oosthuizen's earlier heroics gave him a five-shot lead over former British Open champion, 50-year-old Mark Calcavecchia, who is on seven-under 137.
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Meanwhile on the PGA Tour, former British Open champion Louis Oosthuizen of South Africa led after three rounds of the Houston Open.
As a three-time British Open champion, he clearly knows how it works.
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Japanese star Shingo Katayama, former British Open champion Todd Hamilton and South African Rory Sabbatini are in a three-strong group on six-under 210.
Former British Open champion Paul Lawrie of Scotland and Paul Gow of Australia followed at 8 under, while Sweden's Parnevik finished at 7 under.
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The 2011 PGA Championship winner Keegan Bradley, his fellow American Jason Dufner and 2010 British Open champion Louis Oosthuizen are tied on level par.
Choi, from Korea, are two shots back from Fernandez-Castano on four-under while five players were tied on three-under, including 1999 British Open champion Paul Lawrie.
But the 2011 British Open champion has been forced to withdraw with the same hamstring injury which kept him out of last week's Valero Texas Open.
It left him in a group on 133 while former British Open champion Louis Oosthuizen of South African was in second place after a 66 for 131.
The 2010 British Open champion won by two shots from Tjaart Van der Walt with another South African Retief Goosen in third place, a further shot behind.
British Open champion Darren Clarke also recorded a round of 70 but fellow Northern Irishman and 2010 U.S. Open champion Graeme McDowell slumped to a round of one-over.
Further birdies at the 13th and 17th saw him card a 67 to lead South Africa's 2010 British Open champion Louis Oosthuizen and Sweden's Peter Hanson by a shot.
On Saturday he carded a four-under-par 68 to move clear of 2010 British Open champion Louis Ooosthuizen (74), Thailand's Thongchai Jaidee (73) and France's world No. 187 Julian Quesne (67).
It had seemed to be a straight battle between 2011 British Open champion Darren Clarke, and Irish compatriot McGinley, who both served as vice captains to Jose Maria Olazabal in Chicago.
South Africa's 2010 British Open champion Louis Oosthuizen made 67 to be tied for seventh on 139 along with Italy's Francesco Molinari (68), Irishman Shane Lowry (70) and Spain's Pablo Larrazabal (68).
Top overseas players Angel Cabrera, Justin Rose, Ernie Els, Geoff Ogilvy, Louis Oosthuizen, Vijay Singh, Jose Maria Olazabal, Graeme McDowell and British Open champion Darren Clarke are also all on their way home.
It was not long before the future British Open champion started tasting success after teaming up with compatriot Charl Schwartzel to win his first title at the World Junior Team Championships in 2000.
Fred Couples' men always looked set to clinch the trophy after British Open champion Stewart Cink gave them a winning 4 and 3 start against Adam Scott in the first match of the day.
He was one shot ahead of Scotland's 1999 British Open champion Paul Lawrie, who was tied in another big group including Frenchmen Thomas Levet and Jean Van de Velde, the runner-up at Carnoustie in 1999.
Wie will take on 11 of the world's top 30 women in the Women's Australian Open at Royal Canberra Golf Club starting Thursday, including top-ranked Yani Tseng, 2012 LPGA Player of the Year Stacy Lewis and two-time British Open champion Jiyai Shin.
Former world No. 1 Luke Donald was tied for seventh on 66, while fellow 2012 Ryder Cup players Ian Poulter, Graeme McDowell, Lee Westwood, Dustin Johnson and Steve Stricker were on 68 in a group also including British Open champion Ernie Els, runner-up Adam Scott and Louis Oosthuizen -- who was second at the Deutsche Bank event.
So with the influence of the phone continuing to grow, how long before spectators are so busy tweeting about the British Open they miss the champion lifting the Claret Jug?
The American ended on 286 in a group including British Open runner-up Adam Scott of Australia, Masters champion Bubba Watson, 2010 U.S. Open champion Graeme McDowell and fellow former major winners Geoff Ogilvy and Ben Curtis.
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