This article reviews the previous investigations concerning effects of eugenol including its analogs on the CNS and describes perspectives of this highly potential compound.
Prior to becoming chairman and CEO of Spectrum, Dr. Shrotriya was the Worldwide Executive Director for CNS (central nervous system) Clinical Research at Bristol Myers-Squibb (BMY), where he worked for 18 years.
CB2 receptors, located predominantly in peripheral tissue, exist at very low levels in the CNS. With the development of receptor-specific antagonists, additional information about the roles of the receptors and endogenous cannabinoids in the modulation of pain has been obtained.