We've seen scientists experiment with DNA as a storage medium -- most recently with a Harvard team fitting 704TB of data onto a single gram of the genetic material -- and it looks like that research trend is only picking up.
Important cases where the computational definition of R2 can yield negative values, depending on the definition used, arise where the predictions which are being compared to the corresponding outcomes have not been derived from a model-fitting procedure using those data, and where linear regression is conducted without including an intercept.
And it seemed very fitting to talk about big data, insight acceleration and real time analytics in the very place where mass and speed of light got combined for posterity, more than a century ago.