In fact, in 2004 the American College of Obstetricians and Gynecologists issued guidelines calling the combination a first-line therapy.

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And they expect Quad to become a widely used first-line therapy, since it consists of a single-tablet regimen and lacks neuropsychiatric side effects.

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"I'm reasserting that naproxen is a good first-line therapy, " he says.

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"It's concerning to us, because we're worried that patients who really aren't experts and read this casually could interpret that the ACC endorse this as a first-line therapy, " says Weaver.

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Some doctors have been using Vytorin as a first-line therapy because it's so easy to give: The lowest dose of this combo pill lowers cholesterol better than higher doses of the other medicines, with fewer side effects.

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