Orion Genomics hopes to start pulling in revenues next year from its proprietary method of sequencing, mapping and cloning agricultural genes--technology that can be used to improve crop yield, develop pest resistance or help plants survive drought, flooding and cold.
Merck is using RNAi technology to switch off genes in lab animals it is using in drug discovery.
The companies are a bit cagey about the details, but according to Robert Dorsch, who works on the DuPont side of things, and Ray Chandra, of Genencor, the technology involves inserting four genes taken from various species of bacteria and yeast into industrial strains of E. coli.
Rosetta brings two technologies to bear on sluggish drug development: chips that have been covered with a series of genes using what is essentially a modified inkjet printing process, and powerful computer algorithms that use pattern recognition technology to show how whole sets of genes are being turned on and off.
He has spent the past 15 years trying to prove a drug technology that shuts down problem genes directly at the DNA level.
Antisense technology prevents disease- related genes from going into action.
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The knock against Monsanto's technology was the use of foreign genes, something that Peribere says zinc fingers can avoid.
The Rosetta purchase gave Merck expertise in figuring out exactly which genes the body is reading--a technology called gene-expression profiling.
Isis was founded in 1989 by Stanley Crooke, the former head of research at SmithKline Beckman, after he saw a technology called antisense that could block genes directly.
He has pioneered the use of technology to study cancer-associated genes and to construct animal models of many human cancer types, including cancers of the lung, pancreas, brain, and ovaries.
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Love insists that Hyseq has a unique gene-finding technology that will help it discover genes that have been missed both by other gene database companies and by the U.S. government-funded Human Genome Project.
To quickly compare the genes, the Genomics Center is using gene sequencing technology developed by Lynx Therapeutics, a biotech partner of Hoechst in Hayward, Calif.
And while Crooke deserves a lot of credit for keeping the technology behind mipomersen alive (it targets genes directly instead of blocking the proteins they make) this year he did a great deal to prove the naysayers right.
If genes are to be the raw material of a new technology, then it would be useful for researchers to know how many there are out there.
In the issue of Nature that also contains the Human Genome Project's paper on the genome, a team of Rosetta scientists outlined how they refocused the company's technology to figure out whether DNA sequences constitute complete genes.
Orchid is betting that it can grow by selling technology that will help other companies understand the mistakes in some people's genes.
Rosetta's technology lets scientists look at that mountain of genetic code from above, helping them pick out the genes they need to know about from the entirety of the genome.
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