Sheffield United were relegated through goal difference after their 2-1 defeat by Wigan at Bramall Lane.
The U.S. and Costa Rica both have four points, but Costa Rica leads on goal difference.
It lifted Milan to fourth in the table on goal difference above city rivals Internazionale.
Orient are currently ninth in the League One table, level on points with Leeds, but behind on goal difference.
In a tight group the second place could be decided on goal difference.
United are top of the league table from the Blues on goal difference with two matches remaining.
Sevilla stayed in fourth place on goal difference from Mallorca, who travel to struggling Zaragoza on Wednesday.
Torquay beat Huddersfield, who drew at Cheltenham, to the third promotion slot by virtue of goal difference.
BBC: SPORT | Football | My Club | Torquay United | Rosenior delight at rise
Once again, Saints were back in the bottom three by goal difference and heading for League One.
Andy Thorn's side move off the bottom of the table on goal difference at the expense of Doncaster.
Unlike the Blues, Twente's goal difference will not help them should they finish level on points with Ajax.
Prior to kick-off, Kilmarnock were above Falkirk, who occupied the automatic relegation spot with an inferior goal difference.
Victory over San Marino could see Northern Ireland leap into second place in Group Three on goal difference.
United are three points ahead of Chelsea with a superior goal difference but have played a game more.
Spurs are three points behind Chelsea, who enjoy an 18-goal advantage over them in the goal difference stakes.
The win boosts Falkirk's superior goal difference over Inverness, who have played a game more than their victors.
The result takes Rangers level on points with leaders Celtic, who boast a superior goal difference by two.
Bari, meanwhile, moved up into fifth place on goal difference above a group of five teams including Fiorentina.
With two games to play, they are six points clear of second-placed Birmingham with a vastly superior goal difference.
The draw leaves Kilmarnock level on points with Aberdeen, although they are now second from bottom on goal difference.
Glenavon go into the game second on goal difference in the table after opening wins over Coleraine and Portadown.
And it rescued a point for Liverpool who are now second in the group, behind Atletico on goal difference.
Uruguay beat Mexico 1-0 to finish top of Group A, meaning the Mexicans qualify in second on goal difference.
Victory for bottom-of-the-table Bognor over fellow strugglers Billericay Town could see them move above the Essex side on goal difference.
But Fulham are only above the drop zone on goal difference and face a trip to eighth-placed Portsmouth on Sunday.
United, who face games against West Ham (home) and Wigan (away), top the table with a vastly superior goal difference.
Palermo climbed up to fourth on goal difference, beating Udinese 1-0 at home with an 87th-minute goal from Cesare Bovo.
Glentoran are three points behind the leaders but they have a game in hand on Cliftonville and a better goal difference.
Fifth-placed Tottenham also have a game in hand on Liverpool and are three points ahead with a slightly better goal difference.
Senegal , meanwhile, moved up to second - behind Congo on goal difference - with a 1-0 win over Zambia .
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