Robert Welbourn finished seventh in the final of the men's 200m individual medley (SM10).
Hannah Miley again lowered the British record for the 200m individual medley but could only finish fourth.
Instead, it reported that Ryan Lochte won the gold medal in the 400-meter individual medley, beating Michael Phelps.
Michael Phelps has a good shot to win the first swimming gold in the 400-meter individual medley Saturday.
Ellie, 17, has won gold in the SM6 200m individual medley as well as the S6 400m freestyle.
Phelps had already won the 200 and 400 individual medley and 200 butterfly and 4x200 freestyle relay golds.
The Games started off slow for Phelps who finished fourth in his first race, the 400 individual medley.
Fellow Welsh athlete Dave Roberts was also pleased with his silver in the men's SM7 200m individual medley.
BBC: SPORT | Other Sport | Paralympics | Kindred leads medal haul
Victory in the SM6 200m individual medley gave Ellie her fourth Paralympic title.
Grainne Murphy missed out on a third medal at the championships after finishing seventh in Sunday's 400m individual medley final.
ParalympicsGB swimming sensation Ellie Simmonds won her second 2012 gold with a world record in the SM6 200m individual medley on Monday.
Earlier Phelps added the 200m butterfly gold to his 400m individual medley title, but was unhappy not to better his own world record.
Steve Furniss, bronze medalist in the men's 200-meter individual medley swimming event in the 1972 Olympics in Munich, went on to make swimsuits for champions.
Fellow Brit Heather Frederiksen produced a stunning last 50m to touch out Russia's Olesya Vladykina and take bronze in the in 200m individual medley (SM8).
As a 19-year-old, Phelps won six golds in Athens, in the 100m and 200m butterfly, the 200m and 400m individual medley and the 4x200m free and 4x100m medley relays.
British duo Hannah Miley, who finished sixth in a high-quality 400m individual medley final, and Keri-Anne Payne were both edged out in the 200m individual medley semi-finals.
She will lose the gold she won in the S8 100m freestyle as well as silver from the SM8 200m individual medley and bronze from the S9 100m backstroke.
Ireland's Claire Hogan failed to qualify for the final of the 200m individual medley after finishing 30th fastest in the heats but she again managed a personal best of 2:11.75.
BBC: SPORT | Northern Ireland | Bree unable to repeat heroics
The 2006 Commonwealth Games swimming championships in Melbourne caused great excitement in our school when former pupil David Carry won gold medals in the 400m freestyle and individual medley events.
Rebecca Cooke broke her own British record in the 400m individual medley, in a time of four minutes 46.54 secs, but it was almost five seconds outside the qualifying time for Montreal.
BBC: SPORT | Other Sport | Swimming | Gibson earns place in Montreal
At the top of Saturday's broadcast of NBC Nightly News, Brian Williams, with a spoiler alert proceeding, led with the upset victory of Ryan Lochte over a medal-less Michael Phelps in the 400m individual medley.
If he makes it through the preliminaries, he'll have to swim in the finals of two events on Thursday, Aug. 2 that are just 30 minutes apart: The 200-meter backstroke and the 200-meter individual medley.
Goddard, who won the 200m backstroke title on Wednesday, continued his excellent Commonwealth Games as he won the 200m individual medley in 1:58.10 ahead of Roebuck, who finished in 1.59.86, with Australia's Leith Brodie taking bronze.
Either way, the race offers two fairly safe medals for the U.S. on a night when the Americans are likely to get two more in the women's 400-meter individual medley from Elizabeth Beisel and Caitlin Leverenz, though Australian Stephanie Rice should threaten as well.
Another young swimmer, Tomoko Hagiwara, climbed out of the pool after finishing seventh in her 200-m individual-medley qualifying heat last Monday, her shoulders sagging, her head tilted downward.
He's seeking individual medals in only two styles: fly and medley.
In his previous Olympics, Lochte had sought individual medals in two styles as well: back and medley.
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