"There's no instruction book for this, " Blixt said.

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"This is the first time that we've had a complete chapter in the human instruction book, and that's pretty amazing, " said Dr Francis Collins, from the US National Institutes of Health and who chairs the HGP.

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In any event, thank you for the pleasure and instruction which I got from your book.

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Her latest book, Toddlers: An Instruction Manual, has been crafted with the close help of a traditional publisher.

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By recommending that children be introduced to reading by means of some "easy pleasant book, " Locke pointed the way for the creation by England's John Newbery two generations later of a new type of illustrated children's book in which, unrepentantly, amusement shared pride of place with instruction as the publisher's stated goal.

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