We can't afford to have a cut result in irreversible damage to our industrial base.
Decades of research has shown that lead poisoning causes significant and probably irreversible damage to the brain.
The MRIs can tell how much brain tissue can be saved, and those patients with irreversible damage don't get the drug.
Ecologists were angry with the plan, saying it would destroy Lantau as a green lung and cause irreversible damage to the environment.
But if you've smoked, and then stopped there is irreversible damage, which combined with age-related decline can significantly affect their quality of life.
BBC: Women smokers who quit by 30 'evade earlier death risks'
The center's executive director, Richard Hayes, fears genetic alteration could lead to a race of genetic elites -- or cause irreversible damage to the human race.
Doctors estimate that someone refusing all liquids, depending on factors such as climate and metabolism, could suffer irreversible damage or even die "within five or six days".
Campaigners, with the support of marine scientists, have repeatedly tried to persuade countries to agree to an international ban, arguing that the indiscriminate nature of bottom-trawling is causing irreversible damage to coral reefs and slow-growing fish species, which can take decades to reach maturity and are therefore slow to replenish their numbers.
Strategic blunders at one-time industry leaders such as Sony and Blackberry have caused irreversible financial damage.
FORBES: Judgment Is All: Does JC Penney's Ron Johnson Fatally Lack It?
However, to build the dams often cause irreversible environmental damage despite the fact that the mills do not emit harmful CO2 emissions into the atmosphere.
FORBES: In Brazil, Protesters Shut Down World's Largest Hydro Dam Project
The FDA reviewers said they did not know whether long-term use of mipomersen could cause irreversible liver damage, but warned that patients could be at risk for cirrhosis and liver-related death if the observed liver changes progressed.
The CHMP was also concerned by liver test results in patients taking Kynamro showing a build-up of fat in the liver and increased enzyme levels, and was not convinced that the company had proposed sufficient measures to prevent the risk of irreversible liver damage.
FORBES: CHMP Recommends Against Approval For Mipomersen In Europe
There has been vociferous local and national debate against them, with the anti-dams campaign, Patagonia sin Represas (Patagonia without Dams) emphasising irreversible social and environmental damage.
Boost Mobile and Kyocera recognize that mobile phone accidents happen, but unlike cracked screens or broken keypads that can be replaced, water damage is usually irreversible.
The damage malnutrition does in the first 1, 000 days of life is also irreversible.
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