He retired six in a row before Jayson Nix singled to start the third.
After an intentional walk to Jayson Nix to load the bases, pinch-hitter Travis Hafner struck out.
Jayson Nix led off with a single and went to third on Brett Gardner's double.
The slight hiccup allowed Jayson Nix to reach second safely and Overbay to be safe at first.
Jayson Nix hit a leadoff single, went to second on a wild pitch and advanced on Stewart's sacrifice.
In the fifth, the Yankees used three singles, two wild pitches and a grounder by Jayson Nix to score twice.
Jayson Nix followed with a single that dropped just in front of charging right fielder Mike Baxter for a 1-0 lead.
Jayson Nix struck out, and Lyle Overbay fouled off three two-strike pitches and singled softly to center, driving in two runs.
Astros starter Erik Bedard fell behind after 11 pitches when Suzuki hit a leadoff triple and scored on Jayson Nix's single.
He struck out Brett Gardner and retired Jayson Nix on a popup.
Jayson Nix and Brett Gardner reached on singles, and Cano sent a long drive to right-center for his seventh homer of the year.
Cobb (3-1) gave up only two hits through the eighth Eduardo Nunez's second-inning single and an infield single by Jayson Nix in the sixth.
Lefty Oliver Perez (1-0), his career revived in Seattle, entered with runners at the corners and struck out Gardner and retired Jayson Nix on a popup.
Jayson Nix, filling in for Derek Jeter's injured backup, Eduardo Nunez, failed to field a routine grounder that allowed leadoff batter Austin Jackson to reach first.
The Rays' advantage grew to 3-1 when Joyce slid home safely under catcher Austin Romine's tag attempt after Yunel Escobar hit a grounder to shortstop Jayson Nix.
Suzuki followed a walk by Travis Hafner with his two-run shot in the second inning, and Overbay followed a double by Jayson Nix with his two-run homer.
Napoli's second slam of the season came after Stewart and shortstop Jayson Nix visited Hughes when the count reached 2-2 Hughes said it was to change signs.
In a lineup dominated by prospects, the Yankees made five errors, by Turley, shortstop Jayson Nix, third basemen Corban Joseph and Walter Ibarra, and second baseman Jose Pirela.
John Buck beat the defensive shift with an RBI single to right and the Mets scored again when third baseman Jayson Nix bobbled Marlon Byrd's RBI grounder for an error.
Jayson Nix, filling in for the fill-in shortstop, Kevin Youkilis at third base and Lyle Overbay on first completed the Yankees' first triple play in the Bronx in 45 years.
Romine and Brett Gardner had run-scoring hits, Robinson Cano hit an RBI grounder and Jayson Nix had two sacrifice flies in dropping Buehrle to 1-10 in 15 starts against the Yankees.
Jayson Nix had an RBI infield single and Brennan Boesch a run-scoring fielder's choice for the banged-up Bronx Bombers, who bounced back from a 9-1 loss to the Astros on Monday.
Out since injuring his right wrist March 5, Teixeira worked out a seven-pitch walk in the second inning in his first plate appearance of the season and scored on Jayson Nix's single.
In other roster news, Yankees manager Joe Girardi said infielder Jayson Nix, outfielder Ben Francisco and right-hander Shawn Kelley have made the team, while right-hander David Aardsma has been designated for assignment.
Suzuki singled with one out in the eighth, went to third on Jayson Nix's single to left, and scored to get the Yankees even at 2 when Brett Gardner hit a grounder to second.
Sean Doolittle (2-0) pitched a perfect seventh, and Ryan Cook got out of a two-on, one-out jam in the eighth by striking out Jayson Nix and retiring Lyle Overbay on a flyout to deep center.
Given a 2-0 lead in the second on RBI singles from Jayson Nix and Ichiro Suzuki, Sabathia improved to 9-2 with a 2.63 ERA in 13 starts following Yankees losses since the start of the 2012 season.
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