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Wawrinka, the 18th seed, won 6-4 7-5 against Australian veteran Lleyton Hewitt, who on Saturday beat last year's losing finalist John Isner.
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The winner of that match will play either fifth seed Petrova or last year's losing finalist, 10th seed Flavia Pennetta of Italy.
CNN: No. 1 Safina first to reach WTA showpiece
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Peer, who beat 13th seed Yanina Wickmayer of Belgium in the first round, defeated last year's losing finalist Virginie Razzano of France 6-2 6-2.
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Tilden never won the French Open, being losing finalist in the last year it was held on grass courts, in 1927, and 1930 on clay.
CNN: Bill Tilden: Profile of a tennis legend
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The Dutch indoor hardcourt event is missing defending champion Andy Murray and last year's losing finalist Nadal, so world No. 3 Novak Djokovic is the top seed.
CNN: Soderling survives scare in Rotterdam
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Open title in 1929 as well as being twice a losing finalist, goes down in the history books as one of the greatest tennis players of all time.
CNN: Federer closes on Tilden's U.S. Open record
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Sixth seed Roddick, last weekend's losing finalist, gave home fans some cheer as he crushed Russia's Igor Andreev 6-4 6-4 to set up a clash with Ukraine's Sergiy Stakhovsky.
CNN: Djokovic dumped out in Miami; Clijsters and Henin progress
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Tilden, who claimed his seventh U.S. Open title in 1929 as well as being twice a losing finalist, goes down in the history books as one of the greatest tennis players of all time.
CNN: Bill Tilden: Profile of a tennis legend