As Forbes wrote in March, Merck has a killer app when it comes to making copycat proteins (see "Needle Work").

FORBES

But Shepherd Smith of Americans for a Sound AIDS-HIV Policy, which opposes needle exchanges, says there are "troubling aspects" to studies that show needle exchange programs work.

CNN: Congresswoman urges end to federal funding ban

Candy watched as Marjorie attempted to work the needle through the material in the seed-size stitches required for the seam she was sewing.

NEWYORKER: The Visitor

Put differently, how can documentary filmmakers working on long-standing social and political issues ensure that their work is well poised to move the needle on their chosen topic in a significant way?

FORBES: Shifting Narratives Through Documentary Film: A Case Study of 'Budrus'

Private citizens, innovative businesses, and philanthropic organizations dedicated to the education and success of entrepreneurs (like the Kauffman Foundation), are all finding innovative ways to work on moving the job-creation needle.

FORBES: Can Crowdfunding Create Jobs and Will The Government Help?

Dr Martin Mueller, one of the researchers behind this work, says that the greater damage to the body caused by the tattoo needle may explain the better immune response.

BBC: More antibodies are created with the tattooing method

All of these choices have moved the chronically high unemployment needle exactly the opposite direction at a time when Americans are desperate to get back to work and get their families back on firmer financial footing.

FORBES: What Obama Has Done, Not What He Says -- Matters

He showed it to an expert, who found the needle-and-thread theory "entirely original, " says Mr. Humphrey, whose own scholarly work has examined arenas for Roman chariot racing.

WSJ: On Pins and Needles: Stylist Turns Ancient Hairdo Debate on Its Head