But the clubs most at risk are likely the newly promoted teams Southampton, Reading and West Ham.
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Runners-up Celtic visit Aberdeen, while newly promoted St Johnstone open their campaign at home to Motherwell.
Newly promoted Southampton and second year team Norwich City tie for the third and final relegation position.
Newly promoted Sunderland and Millwall Lionesses will meanwhile be looking to re-establish themselves in the top flight.
China's recent history shows that going soft on dissent can be politically suicidal for any newly promoted leader.
Presumably, this failure now falls on the shoulders of newly promoted Craig Federighi.
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Established, once-consistent winners are starting to lose to up-and-comers and newly promoted clubs, leading to greater unpredictability week after week.
Season ticket holders at newly promoted Cardiff City are being given a say on the colour of shorts for the Premier League kit.
Manchester United needs two goals in the final five minutes from Robin van Persie to beat newly promoted Southampton 3-2 in the Premier League.
The two newly promoted clubs, Fulham and Nottingham Forest, will have survival as their main aim in what could be a hotly contested bottom end of the table.
Samir Nasri scored the clinching goal with 10 minutes left at the Etihad Stadium to end the bold challenge of the newly promoted visitors, who had threatened a victory of their own.
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Jones said Cardiff have had no bids for Ledley and Scotland international striker McCormack, who scored 21 league goals last season, while newly promoted Premier League side Birmingham appear to have got their man in Johnson.
Indeed, if you look at the performance and approach of the newly promoted clubs, you might just find a completely unexpected secret to sudden Premier League success: players who have never before played in the Premier League.
But the newly promoted Tangerines, who make their Premier League bow at Wigan on Saturday, announced on Wednesday the capture of Manchester United's Craig Cathcart, Elliot Grandin from CSKA Sofia, Monaco's Malaury Martin and and Ludovic Sylvestre from Czech side Mlada Boleslav.
Carsley said he also received offers from Derby and newly-promoted West Brom, but chose recently-relegated Birmingham.
Newly-promoted Premier League side Stoke City would like to sign Carson but would have problems finding the fee.
Defender Oscar Ntwagae, who plays for newly-promoted Silver Stars, was one of the surprise invitees for the Lesotho game.
Not to mention the fact that star players might be held out of action on certain UEFA dates, due to the perceived weakness of newly-promoted UEFA opponents.
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Toshack also pointed out that Hennessey's place could be under increasing pressure from Hull's Boaz Myhill who is likely to playing regularly in the top flight with his newly-promoted club.
That leaves just half of the top flight's clubs to contest the campaign's first six weeks, during which newly-promoted Liverpool and Watford will aim to collect vital points.
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There were also opening-day wins for Sunderland at Bolton, with new signing Darren Bent scoring the only goal, and Stoke City, who triumphed 2-0 at home to newly-promoted Burnley.
Manager Ian Holloway's newly-promoted Tangerines looked on course for a momentous three points as they came from behind after Bobby Zamora - watched by England coach Fabio Capello - headed Fulham into a first-half lead.
After losing to bottom side QPR and drawing with newly-promoted Southampton in their last two home games the pressure was on Benitez to deliver and his side consolidated third place thanks to goals from Spain international Juan Mata and Frank Lampard.
We aren't apt to ever hear this in official fashion, but Bloomberg has it on good authority that Apple's newly-promoted Eddy Cue has just fired the guy who was unfortunately leading the Maps team at the time of iOS 6's release.
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Things got even better for the Pilgrims, who were Division Two champions in 2003-4 and were promoted to the newly created Coca Cola Championship.
The Rhinos have also confirmed that former Head of Youth Conditioning Richard Hunwicks has been promoted to the full-time staff in a newly created position of assistant conditioner, working under Jason Davidson.
Promoted Dunfermline Athletic face a trip to Annan in the newly branded Scottish Communites League Cup.
Three weeks ago Wojcicki was promoted to senior vice president in charge of product management and engineering, one of seven generals reporting to newly installed commander-in-chief Larry Page.
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