The firm's shares have almost halved in value this year and talk that it may be in further trouble left it as the biggest loser on the FTSE 100 on Thursday, closing down 4.9%.

BBC: Northern Rock has been heavily hit by the sub-prime crisis

The result: both the biggest dollar gainer and the biggest dollar loser on The Forbes 400 come from tech.

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In Hong Kong, Cathay Pacific's stock was the biggest loser on the exchange.

CNN: Airlines worldwide face $20B tab

But now, fueled by growing awareness of the health risks of obesity and the popularity of weight-loss shows such as The Biggest Loser, they seem to be on the rise.

CNN: Fat camps for grown-ups: Do they work?

Spartan Races plans 48 events and projects 300, 000 total participants this year. (A contestant ran one on NBC's "The Biggest Loser" last year.) As participation numbers balloon, the events are attracting consumer-product sponsors including Under Armour, Merrell shoes, Subaru and Dial for Men.

WSJ: Office Workers Run Extreme Obstacle Courses

The gains faded, however, as the session wore on, with Buffett ultimately ending the day as the biggest loser amongst the 50 billionaires whose wealth Forbes tracks in real time.

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The current round of disputes will undoubtedly end up in a trade war, and China, a country extraordinarily dependent on exports, will surely be the biggest loser.

FORBES: Magazine Article

Instead of Cloud Atlas, the second-biggest turkey on our list is A Thousand Words, the latest money-loser from Eddie Murphy.

FORBES: The Biggest Box Office Flops Of 2012

But the biggest loser would be DMG, which is betting on getting lucrative distribution rights in China to Iron Man 3 and using it as a calling card to court other studios circling China.

FORBES: Hollywood's Mr China: Dan Mintz, DMG

The biggest loser was Orexigen, whose obesity drug Contrave was rejected by the FDA on Feb 1.

FORBES: Biotech Busts And Breakthroughs For February