Traversing the Bernese Oberland on a summer holiday had a profound effect on the 19-year-old author-to-be.
Marian Mahoney, governor of HMP Moorland, said the riots had a "profound effect" on the prison.
And this has a profound effect on the weather patterns and on the rainfall events.
Over the next two decades, the internet would have a profound effect on the recruiting industry.
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As with books, the spread of newspapers had a profound effect on European society.
For a generation of American artists and collectors, the Armory Show had a profound effect.
This had a profound effect on him and he died whilst still a fairly young man.
This had a profound effect on the workforce, and it will do more so in the future.
The answers to the above questions have a profound effect on the type of features you're looking for.
Recent events show, though, that events in an otherwise marginalized region can have a profound effect on Americans.
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What we see has a profound effect on what we do, how we feel, and who we are.
The author says that no single innovation will have a more profound effect than the conversion of biological data.
The administration's unilateralism will have a profound effect on future presidents, argues Goldsmith.
He has seen the profound effect tea party activists have had on the Republican Party, much to his consternation.
And they all say the shootings had a profound effect on their lives.
And that process of mental accounting ends up having a profound effect on the way we spend and invest.
The experience was to have a profound effect on his life, and later on his work as an artist.
So he could have a profound effect on the outcome of the ACA in a very short period of time.
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As you might expect, the explosive growth of connected devices is having a profound effect on the marketing research industry.
An impending strike would have a profound effect on what is seen on TV, says TV Guide columnist Mark Schwed.
Prosecutor Llewellyn Sellick said the victim had made a statement saying what happened had had a profound effect on his life.
In the case of Haiti, Miniutti said she believes the devastating images and stories are having a profound effect on the public.
Harriet Jones, director of the Institute of Contemporary British History, argues that the cold war also had a profound effect on domestic politics.
Even so, says Ms Matsui, if prices merely fall at a slower rate, this could have a profound effect on confidence and expectations.
The forces we uncover and put to use will have a profound effect on what we build, how we live and how we think.
University chiefs had described Thursday as "D-Day" and said the decision would have a profound effect on the future of higher education in Northern Ireland.
Its building of a first aircraft carrier was part of that and would have a profound effect on the balance of forces in the region, he said.
We think that the brain rules our decision-making process but it's pretty clear from operations like this that our guts have a very profound effect on how we behave.
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