The world rarely sees someone who has had such a profound impact on so many.
Retrofit program, and it can have a profound impact on reducing healthcare costs for corporate America.
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But her involvement in the campaign has a profound impact on her family, friends and community.
The actions of the federal government can have a profound impact on financial markets.
This demographic trend will have a profound impact on medical costs, businesses, worker efficiency and productivity.
The greed and hubris displayed on these pages had a profound impact on our economic history.
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None of this is to deny that the unions could again have a profound impact on politics.
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Bringing robotics technology to students in disadvantaged communities can have a profound impact at every grade level.
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Indeed, it is in the area of criminal investigation that DNA fingerprinting has had its most profound impact.
Research suggests that the way we wish to perceive ourselves has a profound impact on how we behave.
We remember the profound impact of Lyndon Johnson, Mike Mansfield, Everett Dirksen and Howard Baker on the Senate.
The fact that Jackson asked these questions ultimately had profound impact on AutoNation's ability to survive in 2009.
This is having a profound impact on the market for developing new tests.
And finally, our newest program which is having a profound impact on education in Chicago is the Saturday University.
These new technologies, combined with demographic shifts and globalisation, will have a profound impact on the future of SMEs.
Leonard Kish aptly called patient engagement the blockbuster drug of the century for its profound impact on improving outcomes.
But one way or another, the case of one errant congressman may have a profound impact on the voting pattern.
The study found that the food in the far corner of the room had a profound impact on these predictions.
Some noted French trends of the past such as Japonisme and Chinoiserie have made a profound impact on French culture.
All in all, it had a more profound impact on me than the selfish suicide of a whiny little junkie boy-man.
When integrated into games, virtual worlds and other simulated environments, this technology will have a profound impact on the user's experience.
It's these kind of skills - and others - that would have such a profound impact on teenagers' outlook on life.
It is often the emotional impact of a story that has the most profound impact on the success of the story.
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Mark Zuckerberg is the youngest billionaire on the planet and created something that has already had a profound impact on the world.
But I think the moment we commemorate today, a moment I experienced all alone, had a more profound impact on my life.
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And all of us have to be concerned about a changing climate that could have a profound impact on every single country here.
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Orbach says that switching from coal to natural gas can have a more profound impact on carbon dioxide (CO2) reductions than certain renewable standards.
It was the first time a President had addressed the nation in such an intimate and informal way, and it had a profound impact.
All this could have a profound impact on the United States, which in recent years has absorbed about half of each new Mexican generation.
The Lao government has plans to build a series of dams along the Nam Ou River, which would have a profound impact on the area.
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