While drugmaking has certainly become a more costly and controversial business in recent years, the path to miraculous medicines has never run smooth.
They keep the PC patched, keep its disk drive in good order, make sure its drivers are up-to-date, and generally make it run smooth as silk.
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Rio has received London's top tips on how to run a smooth transport system ahead of the 2016 Olympic and Paralympic Games.
"We've also had a smooth run with no reliability issues in races, " he added.
Happily, the finale is a smooth run, as Bob and a young companion (Nutsa Kukhianidze) make hay at the tables of a casino.
But it has not been a smooth run for the LSE, which is expected to miss its ambitious target of winning 30% of the Dutch market within a year.
Full examined how they enabled the lizard to hang onto ceilings or run up walls and other smooth surfaces at lightening speeds of one meter per second.
That said, barring some catastrophic blunder by the nascent Independent Election and Boundaries Commission (IEBC) that shall be conducting the election, which pollsters predict will be so close between the two leading candidates, Kenyatta and Odinga that a run-off is likely, Kenyan elections are usually smooth affairs.
"The way he skied, he was so light even though he was a big guy, he was so light on the skis, smooth and he could pull it off -- even though if the first run was not that great, he could really do it on the second run, " the Austrian said.
One of my mentors once told me that in order to run a successful company, you need to be exceptional in at least one or two skills, and smooth out the rough edges on everything else.
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Ecclestone denied he was in Madonna to smooth tensions with Ferrari president Luca di Montezemolo, who has been critical of the way F1 is being run.
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