Issue 3: The third nonclinical issue: An unidentified mode of action and clear safety margin for lorcaserin.
Delays happen because air-traffic controllers need to leave a safety margin between aircraft as they take off.
In the absence of information about the mechanism by which these tumors form (and as I have mentioned before there is no possibility of determining this in rats or humans because of the inaccuracy of the definition of the histology of the cell types) we clarify the safety margin in rats relative to humans.
Performance and Safety Materials Gross Margin: The performance and safety materials division has a current gross margin of 27%.
But it did not provide the margin of safety that we needed at this moment.
Therefore, though food inflation is unpleasant, we have a much greater tolerance (margin of safety) for it.
In short, the margin of safety in price-to-book is good enough to give the stock a closer look.
At the low March 2000 valuations REIT investors had that sleep-enhancing cushion known as a margin of safety.
To be clear, this is not a price target but rather more akin to a margin of safety calculation.
Such a purchase is done with a classic Graham and Dodd, value investing, margin of safety it is said.
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Even so, the stock price offers more than a sufficient margin of safety.
They test consumer products and certify them for a margin of safety.
If you buy cheap, you leave yourself a large margin of safety.
If a large part of that is debt, to be serviced in good and bad years alike, the margin of safety is slim.
And collision-avoidance systems will provide an extra margin of safety for the driver of a small car who's worried about being crushed by a larger vehicle.
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Humans are not adapted to these natural chemicals, in which the margin of safety is about tenfold compared with traces in synthetic pesticides (some 10, 000-fold higher).
So I asked Robb to come up with a simple checklist that he thinks could boost the margin of safety if I ever get near a helicopter.
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It provides an important margin of safety. 70% also works in your favor when purchasing real estate, investing for retirement, or making assumptions about future inflation, etc.
We think that long term investors may have an opportunity to buy this game maker because, according to our methodology, the stock has a decent margin of safety.
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Here are some of the stocks that we think have further upside if gold stays flat or continues higher, and according to our methodology, provide a margin of safety in the event of gold deflation.
In his classic book, The Intelligent Investor, Benjamin Graham, proposed that risk averse investors seek a margin of safety, or leave room for error, to protect themselves from both poor decisions and market downturns.
Because what we have done and what we have left undone in thought, word and deed on a national level determines as much as anything else the margin of safety that a prudent investor should require to invest in that nation.
And the majority of people think by a wide margin that we should be maintaining programs like Social Security and Medicare to provide a basic safety net.
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